De La Salle Santiago Zobel School, located in Muntinlupa's Ayala Alabang Village, was made possible through a joint donation of part of the campus's 11-hectare lot by the Ayala Corporation and the Madrigal Family, with the rest of the lot acquired through financing provided by the Filipinas Life Assurance Company.

DLSZ was established on 29 March 1978 to meet the objective of moving the elementary department of De La Salle University on Taft Avenue to a more conducive and suitable learning environment, with a high school department to assure grade school graduates of placement in secondary education. The school opened in June 1978 with Prep to Grade Six Levels. With the addition of Grade 7 the following year, the Grade School department became fully operational in June 1979. In June 1980, the High School Department opened its freshman classes and became fully operational in June 1983.

The DLSZ curriculum is designed towards the formation of the whole person in a continually changing environment. As such, the curriculum equips the learners with essential skills and values to competently deal with the socio-political, cultural, economic, and religious conditions of a society venturing into a growing global community with its fast-paced technology